Bioactive Small Molecules
Medchemexpress LLC Methyl 5-hydroxypyridine-2-carboxylate | 30766-12-2 | 153.14 | 5 G
Methyl 5-hydroxypyridine-2-carboxylate is a phenolic acid found in the stems of Mahonia fortune. It exhibits NO inhibitory effects in vitro. This compound inhibits NO in LPS-stimulated RAW264.7 and BV2 cells, with IC50s of 115.67 and 118.80 μM, respectively. It does not exhibit any cytotoxic effect at concentrations of 6.25-200 μM.
- Inhibits NO in LPS-stimulated RAW264.7 and BV2 cells
- Does not show cytotoxic effect at concentrations of 6.25-200 μM
- Found in the stems of Mahonia fortune
Medchemexpress LLC HY-145597 5mg , KL-11743 CAS:1369452-53-8 Purity:>98%
HY-145597 5mg KL-11743 CAS: 1369452-53-8 KL-11743 is a potent, orally active, and glucose-competitive inhibitor of the class I glucose transporters, with IC50s of 115, 137, 90, and 68 nM for GLUT1, GLUT2, GLUT3, and GLUT4, respectively. KL-11743 specifically blocks glucose metabolism. KL-11743 can synergize with electron transport inhibitors to induce cell death. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Cayman Chemical ANTIBODY L-MImosIn 250mg
A non-protein amino acid that chelates iron and copper; inhibits certain enzymes that contain iron or copper, including arginase (IC50 = 3.7 µM)
![Medchemexpress LLC 2-Methyl-2-(4-(2-methyl-8-(1H-pyrrolo[2,3-b]pyridin-6-yl)-1H-naphtho[1,2-d]imidazol-1-yl)phenyl)p... | 2845104-25-6 | 99.7% | 443.50 g·mol⁻¹ | C27H21N7 | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000287419.png-250.jpg)
Medchemexpress LLC 2-Methyl-2-(4-(2-methyl-8-(1H-pyrrolo[2,3-b]pyridin-6-yl)-1H-naphtho[1,2-d]imidazol-1-yl)phenyl)p... | 2845104-25-6 | 99.7% | 443.50 g·mol⁻¹ | C27H21N7 | 10 MG
An orally active small-molecule dual inhibitor of PI3K and mTOR developed for preclinical cancer research. Supplied as a high-purity solid with recommended solubility and storage conditions for both in vitro and in vivo experiments.
- Dual PI3K and mTOR inhibition with low-nanomolar potency (PI3Kα 3.5 nM; PI3Kδ 4.6 nM; mTOR 21.3 nM)
- High purity suitable for research applications (99.65%)
- Solid, off-white to gray appearance and stable under recommended storage
- Soluble in DMSO (40 mg/mL) and formulatable for in vivo dosing (10% DMSO/corn oil)
- Multiple packaging formats for in vitro and in vivo use
- Includes storage guidance for solutions (-80°C/-20°C) and solids (4°C protected from light)
Cayman Chemical ANTIBODY GLX-351322 5mg
A NOX4 inhibitor (IC50 = 5 µM); selective for NOX4 over NOX2 (IC50 = 40 µM); reduces glucose-induced production of ROS and cytotoxicity in isolated human pancreatic islets at 10 µM; decreases blood glucose levels in an intravenous glucose tolerance test in mice fed a high-fat diet at an estimated 3.8 mg/kg per day
Cayman Chemical ANTIBODY GKT137831 1mg
A dual inhibitor of both NOX1 and NOX4 with Ki values in the range of 100 to 150 nM in cell-free assays of ROS production; displays good oral bioavailability with high plasma concentrations in vivo and attenuates liver fibrosis in mice
Medchemexpress LLC WFDC1/PS20 Human H 50ug | 50ug
WFDC1/PS20 protein has growth inhibitory activity and regulates cell proliferation by hindering cell growth processes Its actions suggest potential effects on various cellular processes in tissue development and homeostasis WFDC1/PS20 Protein Human (His) is the recombinant human-derived WFDC1/PS20 protein expressed by E coli with N-His labeled tag
Cayman Chemical N-Alyl- -SKF 38393hydrob 5mg
A dopamine D1 receptor partial agonist; selective for dopamine D1 over D2 receptors in radioligand binding assays (Kis = 302 and 5,250 nM, respectively); reduces food intake in rats (ED50 = 3.6 mg/kg); reduces cocaine and food self-administration in squirrel monkeys from 0.1-10 mg/kg
Abcam MitoPQ, selective redox cycler, 5 mg, solid, >98% purity, 954.5 Da, C39H46I3N2P, shipping on blue ice, store at +4°C
MitoPQ is a selective and mitochondria-targeted redox cycler, specifically designed to enhance superoxide production in the mitochondrial matrix in both in vitro and in vivo conditions. This innovative compound is composed of a triphenylphosphonium lipophilic cation linked to the redox cycler paraquat, making it a vital tool for research into mitochondrial superoxide's role in pathology and redox signaling.
- Selective, mitochondria-targeted redox cycler
- Increases superoxide production in the mitochondrial matrix
- Composed of triphenylphosphonium and paraquat
- Molecular weight: 954.5 Da
- Purity: >98%
- CAS Number: 1821370-28-8
- Form: Solid
- Molecular formula: C39H46I3N2P
- Solubility in ethanol: 10 mM
- Solubility in DMSO: 100 mM
- Shipping conditions: Blue Ice
- Storage conditions: Store under desiccating conditions at +4°C
Cayman Chemical ANTIBODY CK-869 25mg
An inhibitor of actin polymerization via inhibition of the Arp2/3 complex; inhibits comet tail formation by L. monocytogenes (IC50 = 7 µM); impairs cell adhesion and spreading
Cayman Chemical PB22 5hydroxyquInolIn Isom 5mg
A structural isomer of PB-22; intended for forensic and research purposes
Selleck Chemical LLC Zinc sulfate heptahydrate E2968-50MG
Zinc sulfate heptahydrate is a hydrate that is the heptahydrate form of zinc sulfate Zinc sulfate heptahydrate is a dietary supplement used for zinc deficiency and can also accelerate the rate of healing It is also used in prepration of zinc tris(thiourea) sulphate (ZTS) a semiorganic nonlinear optic (NLO) material that may be useful in laser fusion experiments and in second-harmonic-generation (SHG) devices
![Medchemexpress LLC Propanoic acid, 3-[2-(2-carboxyethoxy)ethoxy]-, 1-(1,1-dimethylethyl) ester | 2086688-99-3 | ≥98.0% | 262.30 | 100 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000364778-logo.png-250.jpg){kind=logo}
Medchemexpress LLC Propanoic acid, 3-[2-(2-carboxyethoxy)ethoxy]-, 1-(1,1-dimethylethyl) ester | 2086688-99-3 | ≥98.0% | 262.30 | 100 MG
Acid-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. This product exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins and is for research use only.
- Peg-based protac linker
- Used in the synthesis of protacs
- For research use only
Medchemexpress LLC HG-10-102-01 | 1351758-81-0 | MFCD28160565 | 99.6% | 377.83 g/mol | C17H20ClN5O3 | 5 MG
HG-10-102-01 is a potent, selective, brain-penetrant small-molecule inhibitor of leucine-rich repeat kinase 2 (LRRK2) for research use. It exhibits low-nanomolar activity against wild-type and G2019S mutant LRRK2 and is supplied as a high-purity solid suitable for cellular and in vivo studies.
- Potent LRRK2 inhibition at low nanomolar concentrations.
- Brain-penetrant profile suitable for central nervous system studies.
- Active against both wild-type and G2019S mutant forms of LRRK2.
- High chemical purity appropriate for research applications.
- Supplied in milligram-scale quantities for laboratory use.
- Molecular formula C17H20ClN5O3; molecular weight 377.83 g/mol.
Medchemexpress LLC 1,3-Propanesultam | 5908-62-3 | MFCD09802220 | 121.16 | 500 MG
1,3-Propanesultam is a bioactive chemical used for the synthesis of active compounds.
- Bioactive chemical
- Used for the synthesis of active compounds
- Solid appearance
- Colorless to off-white